Post #007: My work on intracerebral haemorrhage

London, May 31, 2017

My PhD Thesis in Neuropathology [1] focuses on the development and assessment of in vitro simulation approaches to intracerebral haemorrhage. Most readers will recognise that this devastating pathological entity is hard to simulate in vitro, and is – to a large extent – still uncharted with regards to a number of aspects of its pathophysiology. Moreover, considering that, to date, no effective treatments have been established for the majority of the members of this group of clinical conditions, my recent work provides a small contribution to the development and assessment of novel experimental approaches to intracerebral haemorrhage at the preclinical level, that would: (i) allow for a more reliable simulation of the disease, (ii) serve the 3R principles [2], and (iii) provide the substrate for high-throughput drug-screening applications.

A close friend and colleague of mine who is fully conversant with the challenges and the limitations of the currently-available in vivo experimental approaches to intracerebral haemorrhage, Dr Alexios Bimpis [3], suggested that the work presented in my PhD Thesis is characterised by “accuracy”, “novelty”, and “vision”. Although certainly biased, his kind opinion has been flattering and rewarding. The work may indeed be accurate, novel, and well-positioned within the neuropathopoietic context [4]. However, is this work useful? And if yes, to whom?

This work – as that of other, smarter and more accomplished scientists – is a “contribution”, and as such it will hopefully have citable and non-citable effects in shaping scientific progress. Itself, this work will not produce patents or conclusive answers to biological mechanisms, but it has the potential to shape new methodological approaches – it has the potential to provide a citable basis for other brain researchers to move a step forward. As such, and based on my confidence of it being uncompromised, this work might be useful to a certain few who will bother reading it. Until then, it is only useful to me.

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Notes: [1]: Zarros A. Development and assessment of in vitro simulation approaches to intracerebral haemorrhage. PhD Thesis in Neuropathology, University of Glasgow, Glasgow, 2017; [2]: the 3R principles refer to the more ethical use of animals in scientific testing and are summarized by the words “Replacement”, “Reduction” and “Refinement”; [3]: Consultant Neurosurgeon at the Panarcadic General Hospital, Tripoli, Greece; [4]: a personal vision of the how the assessment of such in vitro simulation approaches to brain diseases should be performed.

Citation: Zarros A. Post #007: My work on intracerebral haemorrhage. azarros.info/blog 2017; 31-May.